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International Journal of Bio-Inorganic Hybrid Nanomaterials
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Kiaie, N., Mehdinavaz Aghdam, R., Ahmadi Tafti, H., Hojati Emami, S., Izadi Mobarakeh, J. (2015). Influence of Solution Temperature and pH on Size and Morphology Improvement of Chitosan Nanoparticles as Protein Delivery Vehicles. International Journal of Bio-Inorganic Hybrid Nanomaterials, 4(1), 21-24.
N. Kiaie; R. Mehdinavaz Aghdam; H. Ahmadi Tafti; Sh. Hojati Emami; J. Izadi Mobarakeh. "Influence of Solution Temperature and pH on Size and Morphology Improvement of Chitosan Nanoparticles as Protein Delivery Vehicles". International Journal of Bio-Inorganic Hybrid Nanomaterials, 4, 1, 2015, 21-24.
Kiaie, N., Mehdinavaz Aghdam, R., Ahmadi Tafti, H., Hojati Emami, S., Izadi Mobarakeh, J. (2015). 'Influence of Solution Temperature and pH on Size and Morphology Improvement of Chitosan Nanoparticles as Protein Delivery Vehicles', International Journal of Bio-Inorganic Hybrid Nanomaterials, 4(1), pp. 21-24.
Kiaie, N., Mehdinavaz Aghdam, R., Ahmadi Tafti, H., Hojati Emami, S., Izadi Mobarakeh, J. Influence of Solution Temperature and pH on Size and Morphology Improvement of Chitosan Nanoparticles as Protein Delivery Vehicles. International Journal of Bio-Inorganic Hybrid Nanomaterials, 2015; 4(1): 21-24.

Influence of Solution Temperature and pH on Size and Morphology Improvement of Chitosan Nanoparticles as Protein Delivery Vehicles

Article 3, Volume 4, Issue 1, Spring 2015, Page 21-24  XML PDF (543.51 K)
Document Type: Research Paper
Authors
N. Kiaie1; R. Mehdinavaz Aghdam email 2; H. Ahmadi Tafti3; Sh. Hojati Emami1; J. Izadi Mobarakeh4
1Department of Tissue Engineering, AmirKabir University of Technology, Tehran, 15875, Iran
2Tehran Heart Hospital Research Center & Nanotechnology Department+Space Transportation Research Institute, Tehran, Iran
3Tehran Heart Hospital Research Center, Tehran, Iran
4Department of Physiology and Pharmacology, Pasteur Institute of Iran, Tehran, 13164, Iran
Abstract
In recent years, utilization of chitosan /tripolyphosphate nanoparticles has been considered greatly as protein delivery vehicles. Effects of a variety of factors on final characteristics of nanoparticles have been studied by many investigators. Although, the objective of this study was to achieve smaller chitosan nano carriers via changing fabrication parameters such as pH and temperature and to elucidate their effect on the size and polydispersity of nanoparticles. Nanoparticles were produced by ionic gellation method and particle’s morphology was shown by field emission scanning electron microscopy (FE-SEM). The results show that with increasing pH value from 4.5 to 6, either poly dispersity or hydrodynamic diameter decreased significantly in a linear trend (R2= 0.94 for size and 0.99 for pdI data). Results of this study could be used for preparing protein loaded chitosan nanoparticles with small sizes in the range of below 120 nanometers which is sympathetic for drug delivery applications.
Keywords
Hydrodynamic diameter; Protein; Chitosan; polymeric nanoparticles; ionic gelation
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