About the journal
International Journal of Bio-Inorganic Hybrid Nanomaterials (Abbreviation: Int J Bio-Inorg Hybrid Nanomater) is an open access, peer-reviewed, print and online, interdisciplinary, quarterly journal devoted to bio-inorganic hybrid nano-materials. IJBIHN focuses on concepts, properties, phenomena and processes related to combination of inorganic materials, nanomaterials and biological systems. IJBIHN publishes high quality original research papers, communications in the form of letters to the editor, review papers, technical reports, book reviews and case studies. Special issues devoted to developments in important topics in nanotechnology and nanobiotechnology research will be published as well.
Topics covered by IJBIHN include but are not limited to:
- Bio-Inorganic Hybrid Nanomaterials
- Application of Bionanomaterials and Nanomaterials
- Fabrication and Characterization of Nanomaterials
- Computational studies and Modeling of Nano-biomaterials and Nanomaterials.
- Manuscript submission, processing and publication of accepted manuscripts are free of charge.
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Recent Articles
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Open Access Article
1 - Studying the relationship between the structure and inhibitory power of some rodenticides
Issue 4 , Vol. 11 , Autumn 2022Considering the specific properties and applications of organic phosphorus compounds, it is important to design molecules with favorable biological potential. In this article, four compounds from the family of phosphoramides with Potential to have antiacetylcholinestera MoreConsidering the specific properties and applications of organic phosphorus compounds, it is important to design molecules with favorable biological potential. In this article, four compounds from the family of phosphoramides with Potential to have antiacetylcholinesterase properties were selected and after synthesis, purification and identification, they were evaluated quantitatively in terms of hydrophobicity and inhibitory power of enzyme acetylcholinesterase. Also, by using PASS software, the biological activities of each compound were investigated and in particular, the percentage of their antiacetylcholinesterase activity was extracted from the computer evaluation results. The obtained results confirm the PASS software in QSAR studies and it is possible to obtain acceptable and useful results that match what is expected in the experiment without spending time and money. The relationship between toxicity and hydrophobicity is such that with increasing logP, IC50 also increases. This relationship means that increasing the hydrophobic character leads to less toxicity of the phosphorus compound. Manuscript profile -
Open Access Article
2 - Linear QSAR study of Sulfonamide drugs using by imperialist competitive algorithm
Issue 4 , Vol. 11 , Autumn 2022Multiple linear regression (MLR) as modeling tools and Imperialist Competitive Algorithm (ICA) as optimization techniques were employed to choose the best set of descriptors for linear -log(IC50) (the empirical negative logarithm half maximal inhibitory concentration) p MoreMultiple linear regression (MLR) as modeling tools and Imperialist Competitive Algorithm (ICA) as optimization techniques were employed to choose the best set of descriptors for linear -log(IC50) (the empirical negative logarithm half maximal inhibitory concentration) prediction of the Sulfonamide derivatives. A high predictive ability was observed for the MLR-ICA model with the best number of empires/ imperialists (nEmp=20) and (nEmp=60) with root mean sum square errors (RMSE) of 0.03375 and 0.036665 in gas phase and in solvent, respectively. The results obtained using the MLR-ICA method indicated that the activity of the derivatives of Sulfonamide depends on different parameters such as HVcpx, RDF090u, E1v, Wap, R5e, Mor15v, MPC08, RDF115p descriptors in the gas phase and including RDCHI,MATS1v, RDF115v, RDF080v, D/Dr06, piPC05,BEHp6 and G3m descriptors in the solvent phase. It was concluded that simultaneous utilization of MLR-ICA method can lead to a more comprehensive understanding of the relation between physico-chemical, structural or theoretical molecular descriptors of drugs to their biological activities and facilitate designing of new drugs. Manuscript profile -
Open Access Article
3 - Synthesis of hydroxyapatite nanoparticles through inverse microemulsions
Issue 4 , Vol. 11 , Autumn 2022This study is focused on the formation of hydroxyapatite (HA) nanoparticles in an inverse microemulsion processing route, in which cyclohexane is used as the organic phase, cetyltrimethylammonium bromide as surfactant phase, n-pentanol as surfactant, and a solution of C MoreThis study is focused on the formation of hydroxyapatite (HA) nanoparticles in an inverse microemulsion processing route, in which cyclohexane is used as the organic phase, cetyltrimethylammonium bromide as surfactant phase, n-pentanol as surfactant, and a solution of Ca(NO3)2 and (NH4)2HPO4 is used as the queous phase. The influence of polyelectrolyte sodium salt of poly acrylic acid (PAA) and a reactant concentration on the final structure of HA nanoparticles were investigated. A wide variety of morphologies were encountered in synthesis which produced rod-like particles (10-15 nm in diameter and 40-50 nm in length), nanosphere particles (5-15 nm in diameter), and needle-like particles (20-30 nm in diameter and 100-200 nm in length). A great structural diversity resulted in the presence of PAA and by reactant concentration alteration. Finally, the synthesized nanoparticles were visualized by transmission electron microscopy (TEM) and identified by FT-IR and X-ray. Manuscript profile -
Open Access Article
4 - Density functional theory study of adsorption of acid red 33 Dye on the single-walled BN nanotubes
Issue 4 , Vol. 11 , Autumn 2022In this study interaction of acid red 33 Dye with (4, 4) armchair open-end boron nitride nanotubes (BNNTs) in interaction (with a length of 7 Å) was investigated. The impacts of the estereoelectronic effect associated with donor-acceptor electron delocalizations, MoreIn this study interaction of acid red 33 Dye with (4, 4) armchair open-end boron nitride nanotubes (BNNTs) in interaction (with a length of 7 Å) was investigated. The impacts of the estereoelectronic effect associated with donor-acceptor electron delocalizations, dipole-dipole interactions and total steric exchange energies on the structural and electronic properties and reactivity of semiconductors of (4, 4) armchair open-end boron nitride nanotube (BNNT) in interaction with acid red 33 Dye was studied based on the Density Functional Theory (DFT) calculations by using the B3LYP/(6-31G, 6-31G* and 6-31+G*) level of theory in gas phase and water solution. Thermodynamic functional analysis indicate that the relative energies (ΔE), free Gibbs energies (ΔG) and enthalpies (ΔH) are negative for (BNNT - acid red 33 Dye) system but the calculated entropies (ΔS) are Positive, suggesting thermodynamic favourability for covalent attachment of Dye on (4, 4) BNNT and this results confirm the structural stability of the BNNT - acid red 33 Dye in both gas and solvent phases. Delocalization of charge density between the bonding or lone pair and antibonding orbitals calculated by NBO (natural bond orbital) analysis. These methods are used as a tool to determine structural characterization BNNTs during the adsorption reactions in the gas phase. In order to investigation of conductivity and electronic properties of (4, 4) open-end boron nitride nanotube (BNNT) in the reaction with acid red 33 Dye, the total electronic energy, dipole moment, orbital energies, charge density, density of state (DOS), energy bond gaps, Adsorption energies (EAd), the global index were calculated. The calculated LUMO-HOMO energy bond gap show that charge density transfer occurs within the molecules and the semi-conductivity of BNNTs could be justified. Manuscript profile -
Open Access Article
5 - Investigating the expression changes of genes involved in the biosynthesis of androgens in prostate adenocarcinoma and benign prostatic hyperplasia
Issue 4 , Vol. 11 , Autumn 2022Prostate cancer (PCa) is the second most frequently diagnosed malignancy in men worldwide. Androgens are critical for normal prostate development and function, as well as prostate cancer initiation and progression. There are various enzymes in the path of androgen biosy MoreProstate cancer (PCa) is the second most frequently diagnosed malignancy in men worldwide. Androgens are critical for normal prostate development and function, as well as prostate cancer initiation and progression. There are various enzymes in the path of androgen biosynthesis, each of which can be a potential target for designing new therapeutic approaches. Studies have shown that the expression profile of genes involved in the biosynthesis of androgens changes in prostate cancer In this study, we investigated the expression changes of 4 genes involved in the biosynthesis of androgens at both transcription and translation levels in 80 patients with prostate adenocarcinoma, 80 adjacent healthy samples and 80 benign hyperplasia (BPH) samples by RT-qPCR and Western Blot methods, which included AR, HSD3B1, HSD3B2, SRD5A2. PCa showed a signifi cant increase in the expression of the gene AR compared with BPH and Ctrl tissues (p=0.0001), as well as signifi cant increase in the expression of the gene SRD5A2 (p=0.0038), HSD3B1 (p=0.0011) and HSD3B2 (p=0.0469) in BPH samples compared with PCa and Ctrl tissues. The results showed the presence and expression of all enzymes in all groups. But as can be seen, the expression levels of SRD5A2 and HSD3B2 proteins in the BPH group are higher than those in the Ctrl and PCa groups. The results of this study showed that there are extensive changes in the expression profile of genes involved in the biosynthesis of androgens in prostate adenocarcinoma and benign hyperplasia, these results support the claim that genes and enzymes involved in the biosynthesis of androgens can be used as diagnostic and therapeutic targets. Manuscript profile -
Open Access Article
6 - Mo(II) recovery from real water samples by adsorption onto superparamagnetic adsorbent as Fe@Mg-Al LDH ions in water samples
Issue 4 , Vol. 11 , Autumn 2022A novel, simple, sensitive and effective method has been developed for removal of Mo(II) on the superparamagnetic adsorbent as Fe@Mg-Al LDH adsorbent. Spectrometry was used to track the effects of Fe@Mg-Al LDH dose, pH extraction, and contact duration on Mo(II) removal MoreA novel, simple, sensitive and effective method has been developed for removal of Mo(II) on the superparamagnetic adsorbent as Fe@Mg-Al LDH adsorbent. Spectrometry was used to track the effects of Fe@Mg-Al LDH dose, pH extraction, and contact duration on Mo(II) removal from sample water. This research also looked at adsorption isotherm models for the sorption of Mo(II). The magnetic Fe@Mg-Al LDH adsorbent Mo(II) adsorption capability was 29.74 mg/g respectively. The Freundlich isotherm model fits the removal of Mo(II) utilizing magnetic Fe@Mg-Al LDH adsorbent. This approach has an outstanding linear range of 0.5-26 mg/L for Mo2+ ions. The limits of detection (LODs) for Mo2+ ions adsorption by magnetic Fe@Mg-Al LDH adsorbent were reached by utilizing a signal-to-noise ratio of 3 (LOD= 2.35 μg/L). These findings show that magnetic Fe@Mg-Al LDH adsorbent is an effective adsorbent for extracting Mo(II) from different sample waters. Manuscript profile
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Open Access Article
1 - A Theoretical Study of H2S and CO2 Interaction with the Single-Walled Nitrogen Doped Carbon Nanotubes
M. Oftadeh M. Rezaeisadat A. RashidiIssue 1 , Vol. 4 , Winter 2015The physical adsorption of hydrogen sulfide and carbon dioxide gases on the zigzag (5,0) carbon nanotubes doped with nitrogen was investigated through the application of B3LYP/6-31G* at the level of theory on Gaussian 03 software. A variety of stable and high abundance MoreThe physical adsorption of hydrogen sulfide and carbon dioxide gases on the zigzag (5,0) carbon nanotubes doped with nitrogen was investigated through the application of B3LYP/6-31G* at the level of theory on Gaussian 03 software. A variety of stable and high abundance structures of nitrogen doped carbon nanotubes were considered in order to study the interaction between the mentioned gases in different situations by taking rotates of sour gas molecules in the inner and outer walls. Features such as correction of energy adsorption, energy gap, dipole moment, charge distribution, conductors and energy barrier as well as the main parameters such as the gas adsorption energy on the nanotubes were obtained. The results suggest that the nitrogen atom in the structure of carbon nanotubes causes to increase the adsorption of hydrogen sulfide and carbon dioxide gases. Adsorption of hydrogen sulfide on the nanotubes is more effective than carbon dioxide. Moreover, for both gases the adsorption processes are thermodynamically favorable. These nanotubes can be economically used to separate sour gases from natural gases and to recover the sulfur. Manuscript profile -
Open Access Article
2 - Review on Graphene FET and its Application in Biosensing
M. BashirpourIssue 1 , Vol. 4 , Winter 2015Graphene, after its first production in 2004 have received lots of attentions from researchers because of its unique properties. High mobility, high sensitivity, high selectivity and high surface area make graphene excellent choice for bio application. One of promising MoreGraphene, after its first production in 2004 have received lots of attentions from researchers because of its unique properties. High mobility, high sensitivity, high selectivity and high surface area make graphene excellent choice for bio application. One of promising graphene base device that has amazingly high sensitivity is graphene field-effect transistor (GFET). This review selectively summarizes the recent progress in fabrication and application of GFET for various biosensors. This article begins with short description and history of ion-sensitive field-effect transistor (ISFET). After that, advantages of graphene ISFET will be summarized. Then, GFET fabrication process including graphene sheet growth different methods, drain/source electrode deposition and lithography and passivation will be discussed. Finally, different application of GFET in detection of Deoxyribonucleic acid (DNA), pH and protein will be present and quality of GFET biosensor will be examined. Manuscript profile -
Open Access Article
3 - An Efficient Green Synthesis of Copper Oxide NanoCrystalline
M. Kargar M. Ghashang M.R. Mohammad ShafieeIssue 2 , Vol. 4 , Spring 2015In this study, a feasible green method for the synthesis of copper oxide nanocrystalline is described by using sour cherry juice which has a significant effect on crystalline size, and morphology. The benefits of the green method, not only nanometer scale are formed but MoreIn this study, a feasible green method for the synthesis of copper oxide nanocrystalline is described by using sour cherry juice which has a significant effect on crystalline size, and morphology. The benefits of the green method, not only nanometer scale are formed but also low-cost method are obtained in a normal atmosphere which it has been used (CH3COO)2Cu.H2O individually as Cu sources. All samples have calcination in 600°C. The effect of sour cherry juice concentration to control crystal growth is investigated by changing the amount of it to 20, 40, and 80 mL, respectively. The synthesized particles are characterized by using X-ray Diffraction (XRD) and Field Emission Scanning Electron Microscopy (FE-SEM). Powder X-ray Diffraction analysis confirms that pure Copper Oxide nanocrystallines are in a single phase monoclinic structure which the average crystalline size has estimated via Williamson-Hall plot from the highest peak of the XRD was among 15-55 nm for all samples. Manuscript profile -
Open Access Article
4 - Influence of Solution Temperature and pH on Size and Morphology Improvement of Chitosan Nanoparticles as Protein Delivery Vehicles
N. Kiaie R. Mehdinavaz Aghdam H. Ahmadi Tafti Sh. Hojati Emami J. Izadi MobarakehIssue 1 , Vol. 4 , Winter 2015In recent years, utilization of chitosan /tripolyphosphate nanoparticles has been considered greatly as protein delivery vehicles. Effects of a variety of factors on final characteristics of nanoparticles have been studied by many investigators. Although, the objective MoreIn recent years, utilization of chitosan /tripolyphosphate nanoparticles has been considered greatly as protein delivery vehicles. Effects of a variety of factors on final characteristics of nanoparticles have been studied by many investigators. Although, the objective of this study was to achieve smaller chitosan nano carriers via changing fabrication parameters such as pH and temperature and to elucidate their effect on the size and polydispersity of nanoparticles. Nanoparticles were produced by ionic gellation method and particle’s morphology was shown by field emission scanning electron microscopy (FE-SEM). The results show that with increasing pH value from 4.5 to 6, either poly dispersity or hydrodynamic diameter decreased significantly in a linear trend (R2= 0.94 for size and 0.99 for pdI data). Results of this study could be used for preparing protein loaded chitosan nanoparticles with small sizes in the range of below 120 nanometers which is sympathetic for drug delivery applications. Manuscript profile -
Open Access Article
5 - Studying the relationship between the structure and inhibitory power of some rodenticides
Issue 4 , Vol. 11 , Autumn 2022Considering the specific properties and applications of organic phosphorus compounds, it is important to design molecules with favorable biological potential. In this article, four compounds from the family of phosphoramides with Potential to have antiacetylcholinestera MoreConsidering the specific properties and applications of organic phosphorus compounds, it is important to design molecules with favorable biological potential. In this article, four compounds from the family of phosphoramides with Potential to have antiacetylcholinesterase properties were selected and after synthesis, purification and identification, they were evaluated quantitatively in terms of hydrophobicity and inhibitory power of enzyme acetylcholinesterase. Also, by using PASS software, the biological activities of each compound were investigated and in particular, the percentage of their antiacetylcholinesterase activity was extracted from the computer evaluation results. The obtained results confirm the PASS software in QSAR studies and it is possible to obtain acceptable and useful results that match what is expected in the experiment without spending time and money. The relationship between toxicity and hydrophobicity is such that with increasing logP, IC50 also increases. This relationship means that increasing the hydrophobic character leads to less toxicity of the phosphorus compound. Manuscript profile -
Open Access Article
6 - Catalytic Decomposition of H2O2 on MnFe2O4 Nanocomposites Synthesized by Various Methods in the Presence of Silicate and Zeolite Supports
Issue 2 , Vol. 2 , Spring 2013In this research iron manganese oxide nanocomposites were prepared by co-precipitation, sol-gel and mechanochemical methods by using iron (III) nitrate, iron (II) sulfate and manganese (II) nitrate as starting materials. These nanocomposites were prepared in the presenc MoreIn this research iron manganese oxide nanocomposites were prepared by co-precipitation, sol-gel and mechanochemical methods by using iron (III) nitrate, iron (II) sulfate and manganese (II) nitrate as starting materials. These nanocomposites were prepared in the presence of various catalyst beds. The polyvinyl pyrrolidon (PVP) was used as a capping agent to control the agglomeration of the nanoparticles. Nanocatalysts were identified by FT-IR, XRD,SEM and TEM. The sizes of nanoparticles were determined by XRD data and Scherer equation. The prepared nanocatalysts were tested for decomposition of hydrogen peroxide. The hydrogen peroxide decomposition activity of samples was determined by evolved oxygen volumetry technique. Also based on surface area analysis and BET data, using of sodium metasilicate bed led to the high surface area and catalytic activity. Therefore Coprecipitation method in the presence of sodium metasilicate introduce as preferred method. To optimize the catalytic activities of nanoparticles factors such as concentration, cations ratio, pH and calcination temperature were investigated. Manuscript profile -
Open Access Article
7 - Cubic NiO Nanoparticles: Synthesis and Characterization
A.A. Dehno Khalaji D. Das J.S. Matalobos F. GharibIssue 2 , Vol. 4 , Spring 2015In this paper, cubic nickel oxide nanoparticles were successfully prepared by solid-state thermal decomposition of nickel(II) macrocyclic Schiff-base complex at 450°C for 3 h without employing toxic solvent or surfactant and complicated equipment. nickel(II) macrocy MoreIn this paper, cubic nickel oxide nanoparticles were successfully prepared by solid-state thermal decomposition of nickel(II) macrocyclic Schiff-base complex at 450°C for 3 h without employing toxic solvent or surfactant and complicated equipment. nickel(II) macrocyclic Schiff-base complex was synthesized by the reaction of 1,2-bis(2-formyl-3-methoxyphenyl)propane, NiCl2•6H2O and 1,3-phenylenediamine in methanol at room temperature and characterized by elemental analyses and FT-IR spectroscopy. The as prepared NiO nanoparticles were characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray powder diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The XRD pattern result shows that the synthesized NiO nanoparticles are pure and single phase. The SEM and TEM results show the morphology of the as prepared NiO nanoparticles is almost cubic shape with the average size between 20-150 nm. On the basis of the above results, other transition metal macrocyclic Schiff base complexes are therefore potentially capable of forming metal oxide nanoparticles. Manuscript profile -
Open Access Article
8 - Synthesis Silver Nanoparticles by Recovery Silver from Anode Slime of Kerman Sarcheshmeh Cooper Complex
H. Zahedi A. Mollahosseini E. NoroozianIssue 1 , Vol. 4 , Winter 2015According to circumstance of kerman sarcheshmeh cooper complex that its anode slime is mainly consisted of Cu, Ag, Au, Pb and Se. In this work, recovery of silver from anode slime and subsequent synthesis of silver nanoparticles from leaching solution was made. Silver w MoreAccording to circumstance of kerman sarcheshmeh cooper complex that its anode slime is mainly consisted of Cu, Ag, Au, Pb and Se. In this work, recovery of silver from anode slime and subsequent synthesis of silver nanoparticles from leaching solution was made. Silver was separated from anode slime by using of HNO3 and HCl. X-Ray fluorescence spectroscopy (XRF) was used to characterize anode slime components. Silver nanoparticles (SNPs) with average size of 25 nm were obtained through sonication aqueous solution of silver nitrate in the presence of dextrose and polyvinyl pyrrolidone (PVP) as reduction and stabilizing agent respectively. SNPs were characterized by surface plasmon resonance (SPR) and Ultraviolet-Visible (UV-Vis) spectrum. X-Ray diffraction (XRD) pattern confirmed the cubic morphology of metallic SNPs and energy dispersive X-Ray spectroscopy (EDS) spectrum showed peaks of silver free of impurity. Size and distribution of SNPs were determined by dynamic light scattering analysis (DLS) and scanning electron microscopy (SEM). Manuscript profile -
Open Access Article
9 - Application of chemical engineering principles in development of nanomaterials (review)
Issue 4 , Vol. 6 , Autumn 2017Nanotechnology can be applied as a common-purpose technology, as it has important impacts on almost all industries and all areas of science. In those early days, scientists and engineers have confirmed their study on the development of nanomaterials and their applicatio MoreNanotechnology can be applied as a common-purpose technology, as it has important impacts on almost all industries and all areas of science. In those early days, scientists and engineers have confirmed their study on the development of nanomaterials and their applications in various fields. Nanoparticles have a wide range of applications, since it incorporate knowledge from the fields of Physics, Chemistry, Biology, Medicine, and Engineering. Nanomaterials have some special properties due to their small size. The basic applications in the chemical engineering field are catalyst, sensor, coating, and adsorption and drug delivery. Notwithstanding many advantages, preparation and preserving the proper size of nanomaterials are the most desperate job. Chemical engineers play a fundamental role in the modeling and development of nanomaterials. The advances in nanomaterials necessitate parallel progress of the nanometrology tools and techniques to characterize and manipulate nanostructures. In the energy generation, compete where the conventional fuel resources cannot stay the dominant energy source, considering the increasing consumption request and the CO2 emissions further renewable energy sources based on maiden technologies have to be promoted. The present reviews clarify the different nanomaterials using in chemical engineering, their applications and procurement methods. Moreover, results of various patents and research articles have been summarized in this paper. Manuscript profile -
Open Access Article
10 - Electronic Structure Investigation of Octahedral Complex and Nano ring by NBO Analysis: An EPR Study
M. Khaleghian F. Azarakhshi G.R. GhshamiIssue 2 , Vol. 4 , Spring 2015To calculation non-bonded interaction of the [CoCl6]3- complex embedded in nano ring, we focus on the single wall boron-nitride B18N18 nano ring. Thus, the geometry of B18N18 nano ring has been optimized by B3LYP method with EPR-II (Electron paramagnetic resonance) basi MoreTo calculation non-bonded interaction of the [CoCl6]3- complex embedded in nano ring, we focus on the single wall boron-nitride B18N18 nano ring. Thus, the geometry of B18N18 nano ring has been optimized by B3LYP method with EPR-II (Electron paramagnetic resonance) basis set and geometry of the [CoCl6]3- complex has been optimized at B3LYP method with Aldrich’s VTZ basis set and Stuttgart RSC 1997 Effective Core Potential. Also NBO (Natural Bond Orbital) analysis such as LUMO (lowest unoccupied molecular orbital) and the HOMO (highest occupied molecular orbital) for the lowest energy have been derived to estimate the structural stability and band gaps, Natural atomic orbitals, Fermi energy, absorption energy of the B18N18-[CoCl6]3- nano system can be distinguished based on these NBO data. Total atomic charges, Total atomic spin densities, Isotropic Fermi Contact Coupling and geometrical quantities of different loops of B18N18 nano ring inclusive [CoCl6]3- embedded in the nano ring at the level of B3LYP theory and EPR-II basis set for B, N, Cl atoms and Aldrich’s VTZ basis set and Stuttgart RSC 1997 Effective Core Potential for Co (III) have been calculated by Gaussian quantum chemistry package. Manuscript profile
