Synthesis and evaluation of chitosan manganese-ferrite nanoparticles as MRI contrast agent
Document Type : Research Paper
Abstract
Magnetic nanoparticles are the good choice for using in MRI as the contrast agent. Iron oxide particles such as magnetite (Fe3O4) or its oxidized form maghemite (γ-Fe2O3) are the most commonly employed in biomedical applications. In this study, we synthesized and optimized the preparation of chitosan manganese-ferrite nanoparticles (CMn-Fe nps) and evaluated its ability for the mice macrophage cells imaging with MRI. The core and hydrodynamic size of the nanoparticles was 54±27 nm and 149±48 nm respectively. The magnetization reached a saturation magnetization value of 95 emu/g. The MRI images showed that the liver and some other organs were accumulated the CMn-Fe nps and produced a negative contrast in images. CMn-Fe nps demonstrated that it is a good candidate for using as a contrast agent material in macrophage cells imaging with MRI.
(2015). Synthesis and evaluation of chitosan manganese-ferrite nanoparticles as MRI contrast agent. International Journal of Bio-Inorganic Hybrid Nanomaterials, 4(3), 155-159.
MLA
. "Synthesis and evaluation of chitosan manganese-ferrite nanoparticles as MRI contrast agent". International Journal of Bio-Inorganic Hybrid Nanomaterials, 4, 3, 2015, 155-159.
HARVARD
(2015). 'Synthesis and evaluation of chitosan manganese-ferrite nanoparticles as MRI contrast agent', International Journal of Bio-Inorganic Hybrid Nanomaterials, 4(3), pp. 155-159.
VANCOUVER
Synthesis and evaluation of chitosan manganese-ferrite nanoparticles as MRI contrast agent. International Journal of Bio-Inorganic Hybrid Nanomaterials, 2015; 4(3): 155-159.