Comparison of Buspirone adsorption by modification of carboxylated multi-walled carbon nanotube

Document Type: Research Paper

Abstract

To overcome the problems of gene and drug delivery, nanotechnology has gained interest in recent years. Nanosystems with different compositions and biological properties have been extensively investigated for drug and gene delivery applications. Nanotechnology in drug delivery has been manifested into nanoparticles that can have unique properties both in vitro and in vivo, especially in targeted drug delivery to tumors. Carbon nanotubes hold tremendous potential as an effective drug delivery system. The carboxylated multi-walled carbon nanotube was modified by p-amino acetanilide and 5-aminoisophthalic acid. The modified multi-walled carbon nanotube was used to adsorption and determines the amount of Buspirone drug in the human urine. The synthesized adsorbent was characterized using Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX) and Thermogravimetric analysis (TGA). The developed method was utilized for determination of Buspirone drug in pharmaceutical and human urine samples by high performance liquid chromatography (HPLC).

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