Document Type : Research Paper
In this study, a simple and efficient one-pot synthesis of tetrahydrobenzo[b]pyrans from the three-component reaction between dimedone, different aromatic aldehydes and malonitril compounds using NH4Al(SO4)2•12H2O (Alum) as a catalyst at 80 °C is described. As a part of our research works in the synthesis of pyrimidine derivatives containing biological activities, a series of novel pyrano[2,3-d]pyrimidine derivatives 2 were synthesized via reaction of tetrahydrobenzo[b]pyrano derivatives 1 with different reagents in suitable yields. The structures of the entire synthesized compound were well analyzed and their structures established by using various spectral techniques (1H NMR, 13C NMR and IR). Furthermore, all compounds were evaluated for their in vitro antimicrobial activity against different bacterial strains. Antibacterial behavior of product was studied based on reference Gram-positive and Gram- negative bacteria.